Difference between revisions of "YHR216W"
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| − | '''Description of YHR216W:''' Inosine monophosphate dehydrogenase, catalyzes the | + | '''Description of YHR216W:''' Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio<ref name='S000060059'>Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 {{SGDpaper|S000060059}} PMID 11035032</ref><ref name='S000066045'>Shaw RJ, et al. (2001) Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast. J Biol Chem 276(35):32905-16 {{SGDpaper|S000066045}} PMID 11441018</ref><ref name='S000074047'>Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90 {{SGDpaper|S000074047}} PMID 12917348</ref><ref name='S000073958'>Hyle JW, et al. (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8 |
{{SGDpaper|S000073958}} PMID 12746440</ref> | {{SGDpaper|S000073958}} PMID 12746440</ref> | ||
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Revision as of 14:05, 5 February 2010
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| Systematic name | YHR216W |
| Gene name | IMD2 |
| Aliases | PUR5 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:554396..555967 |
| Primary SGDID | S000001259 |
Description of YHR216W: Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio[1][2][3][4]
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References
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- ↑ Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 SGD PMID 11035032
- ↑ Shaw RJ, et al. (2001) Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast. J Biol Chem 276(35):32905-16 SGD PMID 11441018
- ↑ Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90 SGD PMID 12917348
- ↑ Hyle JW, et al. (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8 SGD PMID 12746440
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