Difference between revisions of "YHR191C"

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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Revision as of 13:02, 21 February 2007

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Systematic name YHR191C
Gene name CTF8
Aliases
Feature type ORF, Verified
Coordinates Chr VIII:486631..486230


Description of YHR191C: Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion[1]




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Community Commentary

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Alleles, Strains, and Phenotypes

Complete Deletion

Phenotype(s): Viable

Deletion mutant is defective in telomere positioning to nuclear periphery. [2] [3]


Multiple Knockout Strains

Together with: DCC1, RAD9
Phenotype(s): Viable

ctf8 rad9 double deletion strain is defective in phosphorulation of Rad53p in responce to HU and MMS. [4] [3]




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References

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  1. Mayer ML, et al. (2001) Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell 7(5):959-70 SGD PMID 11389843
  2. Hiraga S, et al. (2006) The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time. EMBO J 25(7):1505-14 SGD PMID 16525505
  3. 3.0 3.1 submitted by Shin-ichiro Hiraga on 2006-06-20
  4. Pan X, et al. (2006) A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 124(5):1069-81 SGD PMID 16487579

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