Difference between revisions of "YHR165C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001208 YHR165C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PRP8 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PRP8 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr VIII:436950..429709 | |nowrap| Chr VIII:436950..429709 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001208 | ||
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<br> | <br> | ||
| − | '''Description of | + | '''Description of YHR165C:''' Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing<ref name='S000074855'>Umen JG and Guthrie C (1995) The second catalytic step of pre-mRNA splicing. RNA 1(9):869-85 {{SGDpaper|S000074855}} PMID 8548652</ref><ref name='S000056376'>Stevens SW and Abelson J (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31 |
{{SGDpaper|S000056376}} PMID 10377396</ref> | {{SGDpaper|S000056376}} PMID 10377396</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 08:45, 27 February 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YHR165C |
| Gene name | PRP8 |
| Aliases | DBF3, DNA39, RNA8, SLT21, USA2 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:436950..429709 |
| Primary SGDID | S000001208 |
Description of YHR165C: Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing[1][2]
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Community Commentary
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Interactions
Two Hybrid
Two Hybrid interaction with Prp40
Prp8 interacts with the U1snRNP protein Prp40 [3] [4]
Two Hybrid interaction with Snp1
Prp8 interacts with the U1snRNP protein Snp1 [5] [4]
Two Hybrid interaction with Exo84
Prp8 binds to C-terminus of Exo84 [6] [4]
Two Hybrid interaction with Prp39
N-terminal region of Prp8 interacts with Prp39 [7] [4]
Two Hybrid interaction with Brr2
C-terminus of Prp8 binds to full length Brr2. N-terminus of Prp8 binds to Prp39 [7] [4]
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References
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- ↑ Umen JG and Guthrie C (1995) The second catalytic step of pre-mRNA splicing. RNA 1(9):869-85 SGD PMID 8548652
- ↑ Stevens SW and Abelson J (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31 SGD PMID 10377396
- ↑ Abovich N and Rosbash M (1997) Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell 89(3):403-12 SGD PMID 9150140
- ↑ 4.0 4.1 4.2 4.3 4.4 submitted by Richard Grainger on 2003-04-11
- ↑ Awasthi S, et al. (2001) New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing. J Biol Chem 276(33):31004-15 SGD PMID 11425851
- ↑ Kuhn AN and Brow DA (2000) Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155(4):1667-82 SGD PMID 10924465
- ↑ 7.0 7.1 van Nues RW and Beggs JD (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67 SGD PMID 11290703
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