Difference between revisions of "YHR157W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YHR157W YHR157W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001200 YHR157W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''REC104 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''REC104 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr VIII:412910..413458
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|nowrap| Chr VIII:412907..413455
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001200
 
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'''Description of {{PAGENAME}}:''' Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination<ref name='S000073936'>Jiao K, et al. (2003) Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p. Mol Cell Biol 23(16):5928-38 {{SGDpaper|S000073936}} PMID 12897161</ref><ref name='S000053571'>Malone RE, et al. (1991) Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics 128(1):79-88 {{SGDpaper|S000053571}} PMID 2060778</ref><ref name='S000046686'>Galbraith AM and Malone RE (1992) Characterization of REC104, a gene required for early meiotic recombination in the yeast Saccharomyces cerevisiae. Dev Genet 13(6):392-402
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'''Description of YHR157W:''' Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination<ref name='S000046686'>Galbraith AM and Malone RE (1992) Characterization of REC104, a gene required for early meiotic recombination in the yeast Saccharomyces cerevisiae. Dev Genet 13(6):392-402 {{SGDpaper|S000046686}} PMID 1304422</ref><ref name='S000073936'>Jiao K, et al. (2003) Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p. Mol Cell Biol 23(16):5928-38 {{SGDpaper|S000073936}} PMID 12897161</ref><ref name='S000053571'>Malone RE, et al. (1991) Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics 128(1):79-88
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{{SGDpaper|S000046686}} PMID 1304422</ref>
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{{SGDpaper|S000053571}} PMID 2060778</ref>
 
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__TOC__
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==Community Commentary==
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=== Interactions ===
 
=== Interactions ===
 
[[Category:Topic:Interactions]]
 
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==Community Commentary==
 
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=== Interactions ===
 
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[[Category:Topic:Interactions]]
 
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==== Physical ====
 
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[[Category:Topic:Interactions:Physical]]
 
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Physical interaction with Rec102 [[Category:Physical Interactions with Rec102]]<br>
 
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Immunoprecipitation and two-hybrid interactions. Both proteins are mutually interdependent for nuclear localization and association with meiotic chromosomes, and both also depend on Spo11p and Ski8p for chromatin association. <ref name='S000082211'>Kee K, et al. (2004) Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J 23(8):1815-24 {{SGDpaper|S000082211}} PMID 15044957</ref> <ref name = 'CAset2960-2005-12-09'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=2960 Scott Keeney] on 2005-12-09</ref>
 
  
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==== Two Hybrid ====
 
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[[Category:Topic:Interactions:Two Hybrid]]
 
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Two Hybrid interaction with Spo11 [[Category:Two Hybrid Interactions with Spo11]]<br>
 
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meiosis-specific two hybrid interaction requires presence of endogenous SKI8 and REC102 genes <ref name='S000075846'>Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 {{SGDpaper|S000075846}} PMID 14992724</ref> <ref name = 'CAset2960-2004-05-02'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=2960 Scott Keeney] on 2004-05-02</ref>
 
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Two Hybrid interaction with Rec114 [[Category:Two Hybrid Interactions with Rec114]]<br> <ref name='S000075846'>Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 {{SGDpaper|S000075846}} PMID 14992724</ref> <ref name = 'CAset2960-2004-05-02'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=2960 Scott Keeney] on 2004-05-02</ref>
 
  
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=== Protein Details ===
 
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==== Protein Localization ====
 
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[[Category:Topic:Protein Details:Protein Localization]]
 
  
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Nuclear localization and association with meiotic chromosomes are dependent on Rec102p. Chromatin association ends abruptly during the pachytene stage of meiosis. <ref name='S000082211'>Kee K, et al. (2004) Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J 23(8):1815-24 {{SGDpaper|S000082211}} PMID 15044957</ref> <ref name = 'CAset2960-2005-12-09'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=2960 Scott Keeney] on 2005-12-09</ref>
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.  
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J Biol Chem 278(5):3265-74</ref>
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==== Protein Modification ====
 
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[[Category:Topic:Protein Details:Protein Modification]]
 
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'''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]]
 
  
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Normal phosphorylation of Rec104p requires the presence of its protein interaction partner, Rec102p. <ref name='S000082211'>Kee K, et al. (2004) Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J 23(8):1815-24 {{SGDpaper|S000082211}} PMID 15044957</ref> <ref name = 'CAset2960-2005-12-09'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=2960 Scott Keeney] on 2005-12-09</ref>
 
  
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==References==
 
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Latest revision as of 07:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YHR157W
Gene name REC104
Aliases
Feature type ORF, Verified
Coordinates Chr VIII:412907..413455
Primary SGDID S000001200


Description of YHR157W: Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination[1][2][3]




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Community Commentary

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Interactions

Physical

Physical interaction with Rec102
Immunoprecipitation and two-hybrid interactions. Both proteins are mutually interdependent for nuclear localization and association with meiotic chromosomes, and both also depend on Spo11p and Ski8p for chromatin association. [4] [5]

Two Hybrid

Two Hybrid interaction with Spo11
meiosis-specific two hybrid interaction requires presence of endogenous SKI8 and REC102 genes [6] [7]

Two Hybrid interaction with Rec114
[6] [7]

Protein Details

Protein Localization

Nuclear localization and association with meiotic chromosomes are dependent on Rec102p. Chromatin association ends abruptly during the pachytene stage of meiosis. [4] [5]

Protein Modification

Modification(s): Phosphorylation

Normal phosphorylation of Rec104p requires the presence of its protein interaction partner, Rec102p. [4] [5]




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References

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  1. ↑ Galbraith AM and Malone RE (1992) Characterization of REC104, a gene required for early meiotic recombination in the yeast Saccharomyces cerevisiae. Dev Genet 13(6):392-402 SGD PMID 1304422
  2. ↑ Jiao K, et al. (2003) Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p. Mol Cell Biol 23(16):5928-38 SGD PMID 12897161
  3. ↑ Malone RE, et al. (1991) Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics 128(1):79-88 SGD PMID 2060778
  4. ↑ 4.0 4.1 4.2 Kee K, et al. (2004) Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J 23(8):1815-24 SGD PMID 15044957
  5. ↑ 5.0 5.1 5.2 submitted by Scott Keeney on 2005-12-09
  6. ↑ 6.0 6.1 Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 SGD PMID 14992724
  7. ↑ 7.0 7.1 submitted by Scott Keeney on 2004-05-02

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