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Systematic name YHR157W
Gene name REC104
Feature type ORF, Verified
Coordinates Chr VIII:412907..413455
Primary SGDID S000001200

Description of YHR157W: Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination[1][2][3]


Community Commentary

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Physical interaction with Rec102
Immunoprecipitation and two-hybrid interactions. Both proteins are mutually interdependent for nuclear localization and association with meiotic chromosomes, and both also depend on Spo11p and Ski8p for chromatin association. [4] [5]

Two Hybrid

Two Hybrid interaction with Spo11
meiosis-specific two hybrid interaction requires presence of endogenous SKI8 and REC102 genes [6] [7]

Two Hybrid interaction with Rec114
[6] [7]

Protein Details

Protein Localization

Nuclear localization and association with meiotic chromosomes are dependent on Rec102p. Chromatin association ends abruptly during the pachytene stage of meiosis. [4] [5]

Protein Modification

Modification(s): Phosphorylation

Normal phosphorylation of Rec104p requires the presence of its protein interaction partner, Rec102p. [4] [5]



See Help:References on how to add references

  1. Galbraith AM and Malone RE (1992) Characterization of REC104, a gene required for early meiotic recombination in the yeast Saccharomyces cerevisiae. Dev Genet 13(6):392-402 SGD PMID 1304422
  2. Jiao K, et al. (2003) Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p. Mol Cell Biol 23(16):5928-38 SGD PMID 12897161
  3. Malone RE, et al. (1991) Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics 128(1):79-88 SGD PMID 2060778
  4. 4.0 4.1 4.2 Kee K, et al. (2004) Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J 23(8):1815-24 SGD PMID 15044957
  5. 5.0 5.1 5.2 submitted by Scott Keeney on 2005-12-09
  6. 6.0 6.1 Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 SGD PMID 14992724
  7. 7.0 7.1 submitted by Scott Keeney on 2004-05-02

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