Difference between revisions of "YHR082C"
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| − | '''Description of YHR082C:''' Ser/thr protein kinase; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10<ref name='S000126103'>Bharucha N, et al. (2008) Analysis of the Yeast Kinome Reveals a Network of Regulated Protein Localization during Filamentous Growth. Mol Biol Cell 19(7):2708-17 {{SGDpaper|S000126103}} PMID 18417610</ref><ref name='S000045656'>Fleischmann M, et al. (1996) Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase. Mol Gen Genet 250(5):614-25 {{SGDpaper|S000045656}} PMID 8676864</ref><ref name='S000148939'>Umekawa M and Klionsky DJ (2012) The Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway. J Biol Chem () | + | '''Description of YHR082C:''' Ser/thr protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10<ref name='S000126103'>Bharucha N, et al. (2008) Analysis of the Yeast Kinome Reveals a Network of Regulated Protein Localization during Filamentous Growth. Mol Biol Cell 19(7):2708-17 {{SGDpaper|S000126103}} PMID 18417610</ref><ref name='S000045656'>Fleischmann M, et al. (1996) Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase. Mol Gen Genet 250(5):614-25 {{SGDpaper|S000045656}} PMID 8676864</ref><ref name='S000147295'>Laxman S and Tu BP (2011) Multiple TORC1-Associated Proteins Regulate Nitrogen Starvation-Dependent Cellular Differentiation in Saccharomyces cerevisiae. PLoS One 6(10):e26081 {{SGDpaper|S000147295}} PMID 22043304</ref><ref name='S000148939'>Umekawa M and Klionsky DJ (2012) The Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway. J Biol Chem () |
{{SGDpaper|S000148939}} PMID 22447937</ref> | {{SGDpaper|S000148939}} PMID 22447937</ref> | ||
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Latest revision as of 14:05, 4 May 2012
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| Systematic name | YHR082C |
| Gene name | KSP1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:271548..268459 |
| Primary SGDID | S000001124 |
Description of YHR082C: Ser/thr protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10[1][2][3][4]
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References
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- ↑ Bharucha N, et al. (2008) Analysis of the Yeast Kinome Reveals a Network of Regulated Protein Localization during Filamentous Growth. Mol Biol Cell 19(7):2708-17 SGD PMID 18417610
- ↑ Fleischmann M, et al. (1996) Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase. Mol Gen Genet 250(5):614-25 SGD PMID 8676864
- ↑ Laxman S and Tu BP (2011) Multiple TORC1-Associated Proteins Regulate Nitrogen Starvation-Dependent Cellular Differentiation in Saccharomyces cerevisiae. PLoS One 6(10):e26081 SGD PMID 22043304
- ↑ Umekawa M and Klionsky DJ (2012) The Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway. J Biol Chem () SGD PMID 22447937
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