Difference between revisions of "YHL022C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YHL022C YHL022C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001014 YHL022C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SPO11 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SPO11 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr VIII:64155..62959
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|nowrap| Chr VIII:64157..62961
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001014
 
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'''Description of {{PAGENAME}}:''' Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation<ref name='S000065880'>Lichten M (2001) Meiotic recombination: breaking the genome to save it. Curr Biol 11(7):R253-6 {{SGDpaper|S000065880}} PMID 11413012</ref><ref name='S000044006'>Keeney S, et al. (1997) Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88(3):375-84
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'''Description of YHL022C:''' Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation<ref name='S000044006'>Keeney S, et al. (1997) Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88(3):375-84 {{SGDpaper|S000044006}} PMID 9039264</ref><ref name='S000065880'>Lichten M (2001) Meiotic recombination: breaking the genome to save it. Curr Biol 11(7):R253-6
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  {{SGDpaper|S000065880}} PMID 11413012</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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=== Interactions ===
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[[Category:Topic:Interactions]]
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==== Two Hybrid ====
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[[Category:Topic:Interactions:Two Hybrid]]
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Two Hybrid interaction with Rec104 [[Category:Two Hybrid Interactions with Rec104]]<br>
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meiosis-specific two hybrid interaction requires presence of endogenous SKI8 and REC102 genes <ref name='S000075846'>Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 {{SGDpaper|S000075846}} PMID 14992724</ref> <ref name = 'CAset2960-2004-05-02'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=2960 Scott Keeney] on 2004-05-02</ref>
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Two Hybrid interaction with ski8 [[Category:Two Hybrid Interactions with ski8]]<br> <ref name='S000075846'>Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 {{SGDpaper|S000075846}} PMID 14992724</ref> <ref name = 'CAset2960-2004-05-02'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=2960 Scott Keeney] on 2004-05-02</ref>
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=== Protein Details ===
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[[Category:Topic:Protein Details]]
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==== Protein Modification ====
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[[Category:Topic:Protein Details:Protein Modification]]
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'''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]]
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Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-27</ref>
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YHL022C
Gene name SPO11
Aliases
Feature type ORF, Verified
Coordinates Chr VIII:64157..62961
Primary SGDID S000001014


Description of YHL022C: Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation[1][2]




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Community Commentary

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Interactions

Two Hybrid

Two Hybrid interaction with Rec104
meiosis-specific two hybrid interaction requires presence of endogenous SKI8 and REC102 genes [3] [4]

Two Hybrid interaction with ski8
[3] [4]

Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [5] [6]




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References

See Help:References on how to add references

  1. ↑ Keeney S, et al. (1997) Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88(3):375-84 SGD PMID 9039264
  2. ↑ Lichten M (2001) Meiotic recombination: breaking the genome to save it. Curr Biol 11(7):R253-6 SGD PMID 11413012
  3. ↑ 3.0 3.1 Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 SGD PMID 14992724
  4. ↑ 4.0 4.1 submitted by Scott Keeney on 2004-05-02
  5. ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  6. ↑ submitted by Jeff Ubersax on 2004-01-27

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