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Systematic name YHL022C
Gene name SPO11
Feature type ORF, Verified
Coordinates Chr VIII:64157..62961
Primary SGDID S000001014

Description of YHL022C: Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation[1][2]


Community Commentary

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Two Hybrid

Two Hybrid interaction with Rec104
meiosis-specific two hybrid interaction requires presence of endogenous SKI8 and REC102 genes [3] [4]

Two Hybrid interaction with ski8
[3] [4]

Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [5] [6]



See Help:References on how to add references

  1. Keeney S, et al. (1997) Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88(3):375-84 SGD PMID 9039264
  2. Lichten M (2001) Meiotic recombination: breaking the genome to save it. Curr Biol 11(7):R253-6 SGD PMID 11413012
  3. 3.0 3.1 Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 SGD PMID 14992724
  4. 4.0 4.1 submitted by Scott Keeney on 2004-05-02
  5. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  6. submitted by Jeff Ubersax on 2004-01-27

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