Difference between revisions of "YGR185C"
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| − | '''Description of YGR185C:''' Cytoplasmic tyrosyl-tRNA synthetase | + | '''Description of YGR185C:''' Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies<ref name='S000047982'>Guan MX (1997) Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae. Mol Gen Genet 255(5):525-32 {{SGDpaper|S000047982}} PMID 9294037</ref><ref name='S000052929'>Cavarelli J, et al. (1993) Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase. Nature 362(6416):181-4 {{SGDpaper|S000052929}} PMID 8450889</ref><ref name='S000054421'>Chow CM and RajBhandary UL (1993) Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis. J Biol Chem 268(17):12855-63 {{SGDpaper|S000054421}} PMID 8509419</ref><ref name='S000059780'>Bare LA and Uhlenbeck OC (1986) Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 25(19):5825-30 {{SGDpaper|S000059780}} PMID 3535890</ref><ref name='S000114313'>Jordanova A, et al. (2006) Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet 38(2):197-202 |
| − | {{SGDpaper| | + | {{SGDpaper|S000114313}} PMID 16429158</ref> |
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Revision as of 14:05, 4 May 2009
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| Systematic name | YGR185C |
| Gene name | TYS1 |
| Aliases | TTS1, TyrRS |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:867525..866341 |
| Primary SGDID | S000003417 |
Description of YGR185C: Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies[1][2][3][4][5]
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References
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- ↑ Guan MX (1997) Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae. Mol Gen Genet 255(5):525-32 SGD PMID 9294037
- ↑ Cavarelli J, et al. (1993) Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase. Nature 362(6416):181-4 SGD PMID 8450889
- ↑ Chow CM and RajBhandary UL (1993) Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis. J Biol Chem 268(17):12855-63 SGD PMID 8509419
- ↑ Bare LA and Uhlenbeck OC (1986) Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 25(19):5825-30 SGD PMID 3535890
- ↑ Jordanova A, et al. (2006) Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet 38(2):197-202 SGD PMID 16429158
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