YGR185C
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| Systematic name | YGR185C |
| Gene name | TYS1 |
| Aliases | TTS1, TyrRS |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:867520..866336 |
| Primary SGDID | S000003417 |
Description of YGR185C: Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies[1][2][3][4][5]
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References
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- ↑ Bare LA and Uhlenbeck OC (1986) Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 25(19):5825-30 SGD PMID 3535890
- ↑ Cavarelli J, et al. (1993) Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase. Nature 362(6416):181-4 SGD PMID 8450889
- ↑ Chow CM and RajBhandary UL (1993) Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis. J Biol Chem 268(17):12855-63 SGD PMID 8509419
- ↑ Guan MX (1997) Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae. Mol Gen Genet 255(5):525-32 SGD PMID 9294037
- ↑ Jordanova A, et al. (2006) Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet 38(2):197-202 SGD PMID 16429158
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