Difference between revisions of "YGL213C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003181 YGL213C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SKI8 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SKI8 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr VII:91251..90058 | |nowrap| Chr VII:91251..90058 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003181 | ||
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<br> | <br> | ||
| − | '''Description of | + | '''Description of YGL213C:''' Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses<ref name='S000075846'>Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 {{SGDpaper|S000075846}} PMID 14992724</ref><ref name='S000058465'>Anderson JS and Parker RP (1998) The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO J 17(5):1497-506 {{SGDpaper|S000058465}} PMID 9482746</ref><ref name='S000050421'>Masison DC, et al. (1995) Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral system. Mol Cell Biol 15(5):2763-71 {{SGDpaper|S000050421}} PMID 7739557</ref><ref name='S000045264'>Brown JT, et al. (2000) The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo. RNA 6(3):449-57 |
{{SGDpaper|S000045264}} PMID 10744028</ref> | {{SGDpaper|S000045264}} PMID 10744028</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 08:46, 27 February 2007
Share your knowledge...Edit this entry! <protect>
| Systematic name | YGL213C |
| Gene name | SKI8 |
| Aliases | REC103 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:91251..90058 |
| Primary SGDID | S000003181 |
Description of YGL213C: Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses[1][2][3][4]
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Contents
Community Commentary
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Interactions
Two Hybrid
Two Hybrid interaction with spo11
[1] [5]
Protein Details
Protein Localization
cytoplasmic localization during vegetative growth, relocalizes to nucleus and onto chromosomes during meiosis [1] [5]
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References
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- ↑ 1.0 1.1 1.2 Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 SGD PMID 14992724
- ↑ Anderson JS and Parker RP (1998) The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO J 17(5):1497-506 SGD PMID 9482746
- ↑ Masison DC, et al. (1995) Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral system. Mol Cell Biol 15(5):2763-71 SGD PMID 7739557
- ↑ Brown JT, et al. (2000) The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo. RNA 6(3):449-57 SGD PMID 10744028
- ↑ 5.0 5.1 submitted by Scott Keeney on 2004-05-02
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