From SGD-Wiki
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YGL213C
Gene name SKI8
Aliases REC103
Feature type ORF, Verified
Coordinates Chr VII:91247..90054
Primary SGDID S000003181

Description of YGL213C: Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype[1][2][3][4][5][6]


Community Commentary

About Community Commentary. Please share your knowledge!


Two Hybrid

Two Hybrid interaction with spo11
[2] [7]

Protein Details

Protein Localization

cytoplasmic localization during vegetative growth, relocalizes to nucleus and onto chromosomes during meiosis [2] [7]



See Help:References on how to add references

  1. Anderson JS and Parker RP (1998) The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO J 17(5):1497-506 SGD PMID 9482746
  2. 2.0 2.1 2.2 Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 SGD PMID 14992724
  3. Brown JT, et al. (2000) The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo. RNA 6(3):449-57 SGD PMID 10744028
  4. Cheng Z, et al. (2004) Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination. Protein Sci 13(10):2673-84 SGD PMID 15340168
  5. Madrona AY and Wilson DK (2004) The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure. Protein Sci 13(6):1557-65 SGD PMID 15152089
  6. Ridley SP, et al. (1984) Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HN. Mol Cell Biol 4(4):761-70 SGD PMID 6371496
  7. 7.0 7.1 submitted by Scott Keeney on 2004-05-02

See Help:Categories on how to add the wiki page for this gene to a Category </protect>