Difference between revisions of "YGL213C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YGL213C YGL213C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003181 YGL213C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SKI8 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SKI8 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr VII:91251..90058
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|nowrap| Chr VII:91247..90054
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003181
 
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'''Description of {{PAGENAME}}:''' Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses<ref name='S000075846'>Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 {{SGDpaper|S000075846}} PMID 14992724</ref><ref name='S000058465'>Anderson JS and Parker RP (1998) The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO J 17(5):1497-506 {{SGDpaper|S000058465}} PMID 9482746</ref><ref name='S000050421'>Masison DC, et al. (1995) Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral system. Mol Cell Biol 15(5):2763-71 {{SGDpaper|S000050421}} PMID 7739557</ref><ref name='S000045264'>Brown JT, et al. (2000) The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo. RNA 6(3):449-57
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'''Description of YGL213C:''' Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype<ref name='S000058465'>Anderson JS and Parker RP (1998) The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO J 17(5):1497-506 {{SGDpaper|S000058465}} PMID 9482746</ref><ref name='S000075846'>Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 {{SGDpaper|S000075846}} PMID 14992724</ref><ref name='S000045264'>Brown JT, et al. (2000) The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo. RNA 6(3):449-57 {{SGDpaper|S000045264}} PMID 10744028</ref><ref name='S000077536'>Cheng Z, et al. (2004) Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination. Protein Sci 13(10):2673-84 {{SGDpaper|S000077536}} PMID 15340168</ref><ref name='S000080394'>Madrona AY and Wilson DK (2004) The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure. Protein Sci 13(6):1557-65 {{SGDpaper|S000080394}} PMID 15152089</ref><ref name='S000054260'>Ridley SP, et al. (1984) Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HN. Mol Cell Biol 4(4):761-70
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  {{SGDpaper|S000045264}} PMID 10744028</ref>
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  {{SGDpaper|S000054260}} PMID 6371496</ref>
 
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==Community Commentary==
 
==Community Commentary==
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YGL213C
Gene name SKI8
Aliases REC103
Feature type ORF, Verified
Coordinates Chr VII:91247..90054
Primary SGDID S000003181


Description of YGL213C: Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype[1][2][3][4][5][6]




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Community Commentary

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Interactions

Two Hybrid

Two Hybrid interaction with spo11
[2] [7]

Protein Details

Protein Localization

cytoplasmic localization during vegetative growth, relocalizes to nucleus and onto chromosomes during meiosis [2] [7]




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References

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  1. ↑ Anderson JS and Parker RP (1998) The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO J 17(5):1497-506 SGD PMID 9482746
  2. ↑ 2.0 2.1 2.2 Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 SGD PMID 14992724
  3. ↑ Brown JT, et al. (2000) The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo. RNA 6(3):449-57 SGD PMID 10744028
  4. ↑ Cheng Z, et al. (2004) Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination. Protein Sci 13(10):2673-84 SGD PMID 15340168
  5. ↑ Madrona AY and Wilson DK (2004) The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure. Protein Sci 13(6):1557-65 SGD PMID 15152089
  6. ↑ Ridley SP, et al. (1984) Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HN. Mol Cell Biol 4(4):761-70 SGD PMID 6371496
  7. ↑ 7.0 7.1 submitted by Scott Keeney on 2004-05-02

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