Difference between revisions of "YFR046C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001942 YFR046C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CNN1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CNN1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VI: | + | |nowrap| Chr VI:244159..243074 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001942 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001942 | ||
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| − | '''Description of YFR046C:''' | + | '''Description of YFR046C:''' Centromere receptor of the microtubule binding Ndc80 complex; histone fold protein involved in kinetochore assembly; interacts with Spc24p and Spc25p, subunits of the essential kinetochore Ndc80 complex and the Nnf1p subunit of the MIS12/MIND complex; phosphorylated by Cdc28p-Clb5p, Ipl1p and Mps1p; orthologous to human CENP-T and fission yeast Cnp20<ref name='S000150766'>Bock LJ, et al. (2012) Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore. Nat Cell Biol 14(6):614-24 {{SGDpaper|S000150766}} PMID 22561345</ref><ref name='S000061559'>Cho RJ, et al. (1998) Parallel analysis of genetic selections using whole genome oligonucleotide arrays. Proc Natl Acad Sci U S A 95(7):3752-7 {{SGDpaper|S000061559}} PMID 9520439</ref><ref name='S000075142'>De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21 {{SGDpaper|S000075142}} PMID 14633972</ref><ref name='S000081002'>Loog M and Morgan DO (2005) Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 434(7029):104-8 {{SGDpaper|S000081002}} PMID 15744308</ref><ref name='S000149670'>Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 {{SGDpaper|S000149670}} PMID 22561346</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 |
| − | {{SGDpaper| | + | {{SGDpaper|S000074306}} PMID 14574415</ref> |
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Latest revision as of 14:05, 4 October 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YFR046C |
| Gene name | CNN1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:244159..243074 |
| Primary SGDID | S000001942 |
Description of YFR046C: Centromere receptor of the microtubule binding Ndc80 complex; histone fold protein involved in kinetochore assembly; interacts with Spc24p and Spc25p, subunits of the essential kinetochore Ndc80 complex and the Nnf1p subunit of the MIS12/MIND complex; phosphorylated by Cdc28p-Clb5p, Ipl1p and Mps1p; orthologous to human CENP-T and fission yeast Cnp20[1][2][3][4][5][6]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]
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References
See Help:References on how to add references
- ↑ Bock LJ, et al. (2012) Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore. Nat Cell Biol 14(6):614-24 SGD PMID 22561345
- ↑ Cho RJ, et al. (1998) Parallel analysis of genetic selections using whole genome oligonucleotide arrays. Proc Natl Acad Sci U S A 95(7):3752-7 SGD PMID 9520439
- ↑ De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21 SGD PMID 14633972
- ↑ Loog M and Morgan DO (2005) Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 434(7029):104-8 SGD PMID 15744308
- ↑ Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 SGD PMID 22561346
- ↑ 6.0 6.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ submitted by Jeff Ubersax on 2004-01-27
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
