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Systematic name YFR046C
Gene name CNN1
Feature type ORF, Verified
Coordinates Chr VI:244159..243074
Primary SGDID S000001942

Description of YFR046C: Centromere receptor of the microtubule binding Ndc80 complex; histone fold protein involved in kinetochore assembly; interacts with Spc24p and Spc25p, subunits of the essential kinetochore Ndc80 complex and the Nnf1p subunit of the MIS12/MIND complex; phosphorylated by Cdc28p-Clb5p, Ipl1p and Mps1p; orthologous to human CENP-T and fission yeast Cnp20[1][2][3][4][5][6]


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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]



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  1. Bock LJ, et al. (2012) Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore. Nat Cell Biol 14(6):614-24 SGD PMID 22561345
  2. Cho RJ, et al. (1998) Parallel analysis of genetic selections using whole genome oligonucleotide arrays. Proc Natl Acad Sci U S A 95(7):3752-7 SGD PMID 9520439
  3. De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21 SGD PMID 14633972
  4. Loog M and Morgan DO (2005) Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 434(7029):104-8 SGD PMID 15744308
  5. Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 SGD PMID 22561346
  6. 6.0 6.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  7. submitted by Jeff Ubersax on 2004-01-27

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