Difference between revisions of "YFR028C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001924 YFR028C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CDC14 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CDC14 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VI: | + | |nowrap| Chr VI:210068..208413 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001924 | ||
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<br> | <br> | ||
| − | '''Description of | + | '''Description of YFR028C:''' Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis<ref name='S000145793'>Bizzari F and Marston AL (2011) Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis. J Cell Biol () {{SGDpaper|S000145793}} PMID 21690308</ref><ref name='S000073259'>Marston AL, et al. (2003) The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation. Dev Cell 4(5):711-26 {{SGDpaper|S000073259}} PMID 12737806</ref><ref name='S000069539'>Saunders WS (2002) The FEAR factor. Mol Cell 9(2):207-9 {{SGDpaper|S000069539}} PMID 11864593</ref><ref name='S000051434'>Taylor GS, et al. (1997) The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression. J Biol Chem 272(38):24054-63 {{SGDpaper|S000051434}} PMID 9295359</ref><ref name='S000047585'>Visintin R, et al. (1998) The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell 2(6):709-18 {{SGDpaper|S000047585}} PMID 9885559</ref><ref name='S000040654'>Wan J, et al. (1992) CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle. J Biol Chem 267(16):11274-80 |
{{SGDpaper|S000040654}} PMID 1597462</ref> | {{SGDpaper|S000040654}} PMID 1597462</ref> | ||
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==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YFR028C |
| Gene name | CDC14 |
| Aliases | OAF3 |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:210068..208413 |
| Primary SGDID | S000001924 |
Description of YFR028C: Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis[1][2][3][4][5][6]
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Community Commentary
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References
See Help:References on how to add references
- ↑ Bizzari F and Marston AL (2011) Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis. J Cell Biol () SGD PMID 21690308
- ↑ Marston AL, et al. (2003) The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation. Dev Cell 4(5):711-26 SGD PMID 12737806
- ↑ Saunders WS (2002) The FEAR factor. Mol Cell 9(2):207-9 SGD PMID 11864593
- ↑ Taylor GS, et al. (1997) The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression. J Biol Chem 272(38):24054-63 SGD PMID 9295359
- ↑ Visintin R, et al. (1998) The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell 2(6):709-18 SGD PMID 9885559
- ↑ Wan J, et al. (1992) CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle. J Biol Chem 267(16):11274-80 SGD PMID 1597462
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