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Systematic name YFR028C
Gene name CDC14
Aliases OAF3
Feature type ORF, Verified
Coordinates Chr VI:210068..208413
Primary SGDID S000001924

Description of YFR028C: Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis[1][2][3][4][5][6]


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  1. Bizzari F and Marston AL (2011) Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis. J Cell Biol () SGD PMID 21690308
  2. Marston AL, et al. (2003) The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation. Dev Cell 4(5):711-26 SGD PMID 12737806
  3. Saunders WS (2002) The FEAR factor. Mol Cell 9(2):207-9 SGD PMID 11864593
  4. Taylor GS, et al. (1997) The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression. J Biol Chem 272(38):24054-63 SGD PMID 9295359
  5. Visintin R, et al. (1998) The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell 2(6):709-18 SGD PMID 9885559
  6. Wan J, et al. (1992) CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle. J Biol Chem 267(16):11274-80 SGD PMID 1597462

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