Difference between revisions of "YFL036W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001858 YFL036W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RPO41 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''RPO41 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VI: | + | |nowrap| Chr VI:58782..62837 |
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001858 |
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| − | '''Description of | + | '''Description of YFL036W:''' Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation<ref name='S000050238'>Greenleaf AL, et al. (1986) Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. Proc Natl Acad Sci U S A 83(10):3391-4 {{SGDpaper|S000050238}} PMID 3517858</ref><ref name='S000146745'>Tang GQ, et al. (2011) Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. J Biol Chem () {{SGDpaper|S000146745}} PMID 21911502</ref><ref name='S000149299'>Velazquez G, et al. (2012) Conservation of Promoter Melting Mechanisms in Divergent Regions of the Single-Subunit RNA Polymerases. Biochemistry () |
| − | {{SGDpaper| | + | {{SGDpaper|S000149299}} PMID 22524540</ref> |
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==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | === Interactions === | ||
| + | [[Category:Topic:Interactions]] | ||
| + | ==== Two Hybrid ==== | ||
| + | [[Category:Topic:Interactions:Two Hybrid]] | ||
| + | Two Hybrid interaction with MTF2 [[Category:Two Hybrid Interactions with MTF2]]<br> | ||
| + | The mitochondrial matrix protein Mtf2p/Nam1p interacts with the amino-terminal domain of mtRNA polymerase (Rpo41p) to couple post-transcriptional events to transcription during mitochondrial gene expression. <ref name='S000060339'>Rodeheffer MS, et al. (2001) Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem 276(11):8616-22 {{SGDpaper|S000060339}} PMID 11118450</ref> <ref name = 'CAset5293-2003-06-05'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5293 Gerald Shadel] on 2003-06-05</ref> | ||
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| + | {{ShortCenteredHR}} | ||
| + | === Protein Details === | ||
| + | [[Category:Topic:Protein Details]] | ||
| + | ==== Protein Function/Process ==== | ||
| + | [[Category:Topic:Protein Details:Protein Function/Process]] | ||
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| + | The amino-terminal extension of Rpo41p contains a functional domain that is dispensible for transcription initiation, but is required for mtDNA stability, suggesting that additional activities are coupled to transcription during mitochondrial gene expression and/or mtDNA replication. <ref name='S000073224'>Wang Y and Shadel GS (1999) Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc Natl Acad Sci U S A 96(14):8046-51 {{SGDpaper|S000073224}} PMID 10393945</ref> <ref name = 'CAset5293-2003-06-06'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5293 Gerald Shadel] on 2003-06-06</ref> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 14:05, 9 May 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YFL036W |
| Gene name | RPO41 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:58782..62837 |
| Primary SGDID | S000001858 |
Description of YFL036W: Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation[1][2][3]
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Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Interactions
Two Hybrid
Two Hybrid interaction with MTF2
The mitochondrial matrix protein Mtf2p/Nam1p interacts with the amino-terminal domain of mtRNA polymerase (Rpo41p) to couple post-transcriptional events to transcription during mitochondrial gene expression. [4] [5]
Protein Details
Protein Function/Process
The amino-terminal extension of Rpo41p contains a functional domain that is dispensible for transcription initiation, but is required for mtDNA stability, suggesting that additional activities are coupled to transcription during mitochondrial gene expression and/or mtDNA replication. [6] [7]
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References
See Help:References on how to add references
- ↑ Greenleaf AL, et al. (1986) Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. Proc Natl Acad Sci U S A 83(10):3391-4 SGD PMID 3517858
- ↑ Tang GQ, et al. (2011) Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. J Biol Chem () SGD PMID 21911502
- ↑ Velazquez G, et al. (2012) Conservation of Promoter Melting Mechanisms in Divergent Regions of the Single-Subunit RNA Polymerases. Biochemistry () SGD PMID 22524540
- ↑ Rodeheffer MS, et al. (2001) Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem 276(11):8616-22 SGD PMID 11118450
- ↑ submitted by Gerald Shadel on 2003-06-05
- ↑ Wang Y and Shadel GS (1999) Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc Natl Acad Sci U S A 96(14):8046-51 SGD PMID 10393945
- ↑ submitted by Gerald Shadel on 2003-06-06
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
