YFL036W
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| Systematic name | YFL036W |
| Gene name | RPO41 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:58782..62837 |
| Primary SGDID | S000001858 |
Description of YFL036W: Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation[1][2][3]
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Contents
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Interactions
Two Hybrid
Two Hybrid interaction with MTF2
The mitochondrial matrix protein Mtf2p/Nam1p interacts with the amino-terminal domain of mtRNA polymerase (Rpo41p) to couple post-transcriptional events to transcription during mitochondrial gene expression. [4] [5]
Protein Details
Protein Function/Process
The amino-terminal extension of Rpo41p contains a functional domain that is dispensible for transcription initiation, but is required for mtDNA stability, suggesting that additional activities are coupled to transcription during mitochondrial gene expression and/or mtDNA replication. [6] [7]
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References
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- Jump up ↑ Greenleaf AL, et al. (1986) Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. Proc Natl Acad Sci U S A 83(10):3391-4 SGD PMID 3517858
- Jump up ↑ Tang GQ, et al. (2011) Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. J Biol Chem () SGD PMID 21911502
- Jump up ↑ Velazquez G, et al. (2012) Conservation of Promoter Melting Mechanisms in Divergent Regions of the Single-Subunit RNA Polymerases. Biochemistry () SGD PMID 22524540
- Jump up ↑ Rodeheffer MS, et al. (2001) Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem 276(11):8616-22 SGD PMID 11118450
- Jump up ↑ submitted by Gerald Shadel on 2003-06-05
- Jump up ↑ Wang Y and Shadel GS (1999) Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc Natl Acad Sci U S A 96(14):8046-51 SGD PMID 10393945
- Jump up ↑ submitted by Gerald Shadel on 2003-06-06
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