Difference between revisions of "YER172C"

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=== Interactions ===
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==== Two Hybrid ====
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Two Hybrid interaction with Prp8 [[Category:Two Hybrid Interactions with Prp8]]<br>
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C-terminus of Prp8 binds to full length Brr2. N-terminus of Prp8 binds to Prp39 <ref name='S000060204'>van Nues RW and Beggs JD (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67 {{SGDpaper|S000060204}} PMID 11290703</ref> <ref name = 'CAset9267-2003-04-11'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9267 Richard Grainger] on 2003-04-11</ref>
  
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==Community Commentary==
 
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=== Interactions ===
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[[Category:Topic:Interactions]]
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==== Two Hybrid ====
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[[Category:Topic:Interactions:Two Hybrid]]
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Two Hybrid interaction with Prp8 [[Category:Two Hybrid Interactions with Prp8]]<br>
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C-terminus of Prp8 binds to full length Brr2. N-terminus of Prp8 binds to Prp39 <ref name='S000060204'>van Nues RW and Beggs JD (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67 {{SGDpaper|S000060204}} PMID 11290703</ref> <ref name = 'CAset9267-2003-04-11'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9267 Richard Grainger] on 2003-04-11</ref>
  
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==References==
 
==References==
 
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Revision as of 17:05, 23 January 2007

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Systematic name YER172C
Gene name BRR2
Aliases PRP44, RSS1, SLT22, SNU246
Feature type ORF, Verified
Coordinates Chr V:536016..529525
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Description of YER172C: RNA-dependent ATPase RNA helicase involved in the facilitation and disruption of snRNA interactions, required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis[1][2][3]



Interactions

Two Hybrid

Two Hybrid interaction with Prp8
C-terminus of Prp8 binds to full length Brr2. N-terminus of Prp8 binds to Prp39 [4] [5]


Community Commentary

About Community Commentary. Please share your knowledge!

Interactions

Two Hybrid

Two Hybrid interaction with Prp8
C-terminus of Prp8 binds to full length Brr2. N-terminus of Prp8 binds to Prp39 [4] [5]


References

See Help:References on how to add references

  1. Raghunathan PL and Guthrie C (1998) RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr Biol 8(15):847-55 SGD PMID 9705931
  2. Xu D, et al. (1996) An RNA-dependent ATPase associated with U2/U6 snRNAs in pre-mRNA splicing. Nature 381(6584):709-13 SGD PMID 8649518
  3. Noble SM and Guthrie C (1996) Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 143(1):67-80 SGD PMID 8722763
  4. 4.0 4.1 van Nues RW and Beggs JD (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67 SGD PMID 11290703
  5. 5.0 5.1 submitted by Richard Grainger on 2003-04-11

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