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Systematic name YER172C
Gene name BRR2
Aliases PRP44, RSS1, SLT22, SNU246
Feature type ORF, Verified
Coordinates Chr V:536021..529530
Primary SGDID S000000974

Description of YER172C: RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD[1][2][3][4]


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Two Hybrid

Two Hybrid interaction with Prp8
C-terminus of Prp8 binds to full length Brr2. N-terminus of Prp8 binds to Prp39 [5] [6]



See Help:References on how to add references

  1. Lauber J, et al. (1996) The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases. EMBO J 15(15):4001-15 SGD PMID 8670905
  2. Noble SM and Guthrie C (1996) Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 143(1):67-80 SGD PMID 8722763
  3. Raghunathan PL and Guthrie C (1998) RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr Biol 8(15):847-55 SGD PMID 9705931
  4. Xu D, et al. (1996) An RNA-dependent ATPase associated with U2/U6 snRNAs in pre-mRNA splicing. Nature 381(6584):709-13 SGD PMID 8649518
  5. van Nues RW and Beggs JD (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67 SGD PMID 11290703
  6. submitted by Richard Grainger on 2003-04-11

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