Difference between revisions of "YEL019C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000745 YEL019C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000745 YEL019C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MMS21 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MMS21 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||'' ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''NSE2, PSO10''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
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'''Description of YEL019C:''' SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination<ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 {{SGDpaper|S000080949}} PMID 15738391</ref><ref name='S000049039'>Montelone BA and Koelliker KJ (1995) Interactions among mutations affecting spontaneous mutation, mitotic recombination, and DNA repair in yeast. Curr Genet 27(2):102-9 {{SGDpaper|S000049039}} PMID 7788712</ref><ref name='S000047995'>Prakash S and Prakash L (1977) Increased spontaneous mitotic segregation in MMS-sensitive mutants of Saccharomyces cerevisiae. Genetics 87(2):229-36
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'''Description of YEL019C:''' SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination<ref name='S000142482'>Bermudez-Lopez M, et al. (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12 {{SGDpaper|S000142482}} PMID 20571088</ref><ref name='S000049039'>Montelone BA and Koelliker KJ (1995) Interactions among mutations affecting spontaneous mutation, mitotic recombination, and DNA repair in yeast. Curr Genet 27(2):102-9 {{SGDpaper|S000049039}} PMID 7788712</ref><ref name='S000047995'>Prakash S and Prakash L (1977) Increased spontaneous mitotic segregation in MMS-sensitive mutants of Saccharomyces cerevisiae. Genetics 87(2):229-36 {{SGDpaper|S000047995}} PMID 200524</ref><ref name='S000080949'>Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82
  {{SGDpaper|S000047995}} PMID 200524</ref>
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  {{SGDpaper|S000080949}} PMID 15738391</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YEL019C
Gene name MMS21
Aliases NSE2, PSO10
Feature type ORF, Verified
Coordinates Chr V:121301..120498
Primary SGDID S000000745


Description of YEL019C: SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination[1][2][3][4]




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References

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  1. Bermudez-Lopez M, et al. (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12 SGD PMID 20571088
  2. Montelone BA and Koelliker KJ (1995) Interactions among mutations affecting spontaneous mutation, mitotic recombination, and DNA repair in yeast. Curr Genet 27(2):102-9 SGD PMID 7788712
  3. Prakash S and Prakash L (1977) Increased spontaneous mitotic segregation in MMS-sensitive mutants of Saccharomyces cerevisiae. Genetics 87(2):229-36 SGD PMID 200524
  4. Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 SGD PMID 15738391

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