YEL019C
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| Systematic name | YEL019C |
| Gene name | MMS21 |
| Aliases | NSE2, PSO10 |
| Feature type | ORF, Verified |
| Coordinates | Chr V:121301..120498 |
| Primary SGDID | S000000745 |
Description of YEL019C: SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination[1][2][3][4]
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References
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- ↑ Bermudez-Lopez M, et al. (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12 SGD PMID 20571088
- ↑ Montelone BA and Koelliker KJ (1995) Interactions among mutations affecting spontaneous mutation, mitotic recombination, and DNA repair in yeast. Curr Genet 27(2):102-9 SGD PMID 7788712
- ↑ Prakash S and Prakash L (1977) Increased spontaneous mitotic segregation in MMS-sensitive mutants of Saccharomyces cerevisiae. Genetics 87(2):229-36 SGD PMID 200524
- ↑ Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 SGD PMID 15738391
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