Difference between revisions of "YDR477W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002885 YDR477W] |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SNF1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SNF1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:1412373..1414274 |
|- | |- | ||
| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002885 |
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<br> | <br> | ||
| − | '''Description of | + | '''Description of YDR477W:''' AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis<ref name='S000081044'>Hardie DG, et al. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67():821-55 {{SGDpaper|S000081044}} PMID 9759505</ref><ref name='S000074313'>Sanz P (2003) Snf1 protein kinase: a key player in the response to cellular stress in yeast. Biochem Soc Trans 31(Pt 1):178-81 |
{{SGDpaper|S000074313}} PMID 12546680</ref> | {{SGDpaper|S000074313}} PMID 12546680</ref> | ||
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__TOC__ | __TOC__ | ||
==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | === Alleles, Strains, and Phenotypes === | ||
| + | [[Category:Topic:Alleles, Strains, and Phenotypes]] | ||
| + | ==== Multiple Knockout Strains ==== | ||
| + | [[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]] | ||
| + | |||
| + | '''Strain Background''': Sigma1278b<br> | ||
| + | '''Genotype''': MCY4461<br> | ||
| + | '''Together with''': REG1<br> | ||
| + | '''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]] | ||
| + | |||
| + | Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Interactions === | ||
| + | [[Category:Topic:Interactions]] | ||
| + | ==== Genetic ==== | ||
| + | [[Category:Topic:Interactions:Genetic]] | ||
| + | YDR477W is suppressed by Nrg2 [[Category:Genetic Interaction with Nrg2]] | ||
| + | |||
| + | |||
| + | '''Strain Background''': Sigma 1278b<br> | ||
| + | '''Mutation type(s)''': complete deletion, complete deletion | ||
| + | |||
| + | Deletion of Nrg2 partially suppresses Snf1's defect in invasive growth, biofilm formation, FLO11 expression, and STA2 expression. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | YDR477W is suppressed by Nrg1 [[Category:Genetic Interaction with Nrg1]] | ||
| + | |||
| + | |||
| + | '''Strain Background''': Sigma 1278b<br> | ||
| + | '''Mutation type(s)''': complete deletion, complete deletion | ||
| + | |||
| + | Deletion of Nrg1 partially suppresses Snf1's defect in invasive growth, FLO11 expression, and STA2 expression. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | ==== Physical ==== | ||
| + | [[Category:Topic:Interactions:Physical]] | ||
| + | Physical interaction with Nrg2 [[Category:Physical Interactions with Nrg2]]<br> | ||
| + | Snf1 coimmunoprecipitates with HA3-Nrg2 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | Physical interaction with Nrg2 [[Category:Physical Interactions with Nrg2]]<br> | ||
| + | LexA-Snf1 coimmunoprecipitates HA3-Nrg2 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | Physical interaction with Nrg1 [[Category:Physical Interactions with Nrg1]]<br> | ||
| + | Snf1 coimmunoprecipitates with HA3-Nrg1 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | Physical interaction with Nrg1 [[Category:Physical Interactions with Nrg1]]<br> | ||
| + | LexA-Snf1 coimmunoprecipitates HA3-Nrg1 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | ==== Two Hybrid ==== | ||
| + | [[Category:Topic:Interactions:Two Hybrid]] | ||
| + | Two Hybrid interaction with Nrg2 [[Category:Two Hybrid Interactions with Nrg2]]<br> | ||
| + | Snf1 kinase domain interacts with Nrg2 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | Two Hybrid interaction with nrg1 [[Category:Two Hybrid Interactions with nrg1]]<br> | ||
| + | Snf1 kinase domain interacts with Nrg1 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | |||
| + | |||
| + | |||
| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
| + | --> | ||
| + | |||
| + | |||
| + | <protect> | ||
==References== | ==References== | ||
<!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
{{RefHelp}} | {{RefHelp}} | ||
| + | </protect> | ||
Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YDR477W |
| Gene name | SNF1 |
| Aliases | CAT1, CCR1, GLC2, HAF3, PAS14 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1412373..1414274 |
| Primary SGDID | S000002885 |
Description of YDR477W: AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis[1][2]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Strain Background: Sigma1278b
Genotype: MCY4461
Together with: REG1
Phenotype(s): Loss of function (Null)
Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. [3] [4]
Interactions
Genetic
YDR477W is suppressed by Nrg2
Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion
Deletion of Nrg2 partially suppresses Snf1's defect in invasive growth, biofilm formation, FLO11 expression, and STA2 expression. [3] [5]
YDR477W is suppressed by Nrg1
Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion
Deletion of Nrg1 partially suppresses Snf1's defect in invasive growth, FLO11 expression, and STA2 expression. [3] [5]
Physical
Physical interaction with Nrg2
Snf1 coimmunoprecipitates with HA3-Nrg2 [6] [5]
Physical interaction with Nrg2
LexA-Snf1 coimmunoprecipitates HA3-Nrg2 [6] [5]
Physical interaction with Nrg1
Snf1 coimmunoprecipitates with HA3-Nrg1 [6] [5]
Physical interaction with Nrg1
LexA-Snf1 coimmunoprecipitates HA3-Nrg1 [6] [5]
Two Hybrid
Two Hybrid interaction with Nrg2
Snf1 kinase domain interacts with Nrg2 [6] [5]
Two Hybrid interaction with nrg1
Snf1 kinase domain interacts with Nrg1 [6] [5]
<protect>
References
See Help:References on how to add references
- ↑ Hardie DG, et al. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67():821-55 SGD PMID 9759505
- ↑ Sanz P (2003) Snf1 protein kinase: a key player in the response to cellular stress in yeast. Biochem Soc Trans 31(Pt 1):178-81 SGD PMID 12546680
- ↑ 3.0 3.1 3.2 Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 SGD PMID 12024013
- ↑ submitted by Valmik K. Vyas on 2003-03-27
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 submitted by Valmik K. Vyas on 2003-02-04
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 SGD PMID 11404322
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
Categories:
- ORF
- ORF, Verified
- Topic:Alleles, Strains, and Phenotypes
- Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains
- Phenotype:Loss of function (Null)
- Topic:Interactions
- Topic:Interactions:Genetic
- Genetic Interaction with Nrg2
- Genetic Interaction with Nrg1
- Topic:Interactions:Physical
- Physical Interactions with Nrg2
- Physical Interactions with Nrg1
- Topic:Interactions:Two Hybrid
- Two Hybrid Interactions with Nrg2
- Two Hybrid Interactions with nrg1
