YDR477W
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| Systematic name | YDR477W |
| Gene name | SNF1 |
| Aliases | CAT1, CCR1, GLC2, HAF3, PAS14 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1412373..1414274 |
| Primary SGDID | S000002885 |
Description of YDR477W: AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis[1][2]
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Contents
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Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Strain Background: Sigma1278b
Genotype: MCY4461
Together with: REG1
Phenotype(s): Loss of function (Null)
Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. [3] [4]
Interactions
Genetic
YDR477W is suppressed by Nrg2
Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion
Deletion of Nrg2 partially suppresses Snf1's defect in invasive growth, biofilm formation, FLO11 expression, and STA2 expression. [3] [5]
YDR477W is suppressed by Nrg1
Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion
Deletion of Nrg1 partially suppresses Snf1's defect in invasive growth, FLO11 expression, and STA2 expression. [3] [5]
Physical
Physical interaction with Nrg2
Snf1 coimmunoprecipitates with HA3-Nrg2 [6] [5]
Physical interaction with Nrg2
LexA-Snf1 coimmunoprecipitates HA3-Nrg2 [6] [5]
Physical interaction with Nrg1
Snf1 coimmunoprecipitates with HA3-Nrg1 [6] [5]
Physical interaction with Nrg1
LexA-Snf1 coimmunoprecipitates HA3-Nrg1 [6] [5]
Two Hybrid
Two Hybrid interaction with Nrg2
Snf1 kinase domain interacts with Nrg2 [6] [5]
Two Hybrid interaction with nrg1
Snf1 kinase domain interacts with Nrg1 [6] [5]
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References
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- Jump up ↑ Hardie DG, et al. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67():821-55 SGD PMID 9759505
- Jump up ↑ Sanz P (2003) Snf1 protein kinase: a key player in the response to cellular stress in yeast. Biochem Soc Trans 31(Pt 1):178-81 SGD PMID 12546680
- ↑ Jump up to: 3.0 3.1 3.2 Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 SGD PMID 12024013
- Jump up ↑ submitted by Valmik K. Vyas on 2003-03-27
- ↑ Jump up to: 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 submitted by Valmik K. Vyas on 2003-02-04
- ↑ Jump up to: 6.0 6.1 6.2 6.3 6.4 6.5 Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 SGD PMID 11404322
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
- ORF
- ORF, Verified
- Topic:Alleles, Strains, and Phenotypes
- Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains
- Phenotype:Loss of function (Null)
- Topic:Interactions
- Topic:Interactions:Genetic
- Genetic Interaction with Nrg2
- Genetic Interaction with Nrg1
- Topic:Interactions:Physical
- Physical Interactions with Nrg2
- Physical Interactions with Nrg1
- Topic:Interactions:Two Hybrid
- Two Hybrid Interactions with Nrg2
- Two Hybrid Interactions with nrg1
