Difference between revisions of "YDR143C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002550 YDR143C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SAN1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SAN1 '' | ||
Latest revision as of 07:45, 23 January 2012
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| Systematic name | YDR143C |
| Gene name | SAN1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:743874..742042 |
| Primary SGDID | S000002550 |
Description of YDR143C: Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition[1][2][3][4]
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Protein Details
Protein Function/Process
Nuclear-localized ubiquitin-protein ligase involved in the proteasome-dependent quality control degradation of aberrant nuclear proteins, including sir4-9, cdc68-1, sir3-8, and cdc13-1. [3] [5]
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References
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- ↑ Dasgupta A, et al. (2004) Sir Antagonist 1 (San1) is a ubiquitin ligase. J Biol Chem 279(26):26830-8 SGD PMID 15078868
- ↑ Fredrickson EK, et al. (2011) Exposed hydrophobicity is a key determinant of nuclear quality control degradation. Mol Biol Cell () SGD PMID 21551067
- ↑ 3.0 3.1 Gardner RG, et al. (2005) Degradation-mediated protein quality control in the nucleus. Cell 120(6):803-15 SGD PMID 15797381
- ↑ Rosenbaum JC, et al. (2011) Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol Cell 41(1):93-106 SGD PMID 21211726
- ↑ submitted by Richard G. Gardner on 2005-11-09
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