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Systematic name YDR143C
Gene name SAN1
Feature type ORF, Verified
Coordinates Chr IV:743874..742042
Primary SGDID S000002550

Description of YDR143C: Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition[1][2][3][4]


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Protein Details

Protein Function/Process

Nuclear-localized ubiquitin-protein ligase involved in the proteasome-dependent quality control degradation of aberrant nuclear proteins, including sir4-9, cdc68-1, sir3-8, and cdc13-1. [3] [5]



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  1. Dasgupta A, et al. (2004) Sir Antagonist 1 (San1) is a ubiquitin ligase. J Biol Chem 279(26):26830-8 SGD PMID 15078868
  2. Fredrickson EK, et al. (2011) Exposed hydrophobicity is a key determinant of nuclear quality control degradation. Mol Biol Cell () SGD PMID 21551067
  3. 3.0 3.1 Gardner RG, et al. (2005) Degradation-mediated protein quality control in the nucleus. Cell 120(6):803-15 SGD PMID 15797381
  4. Rosenbaum JC, et al. (2011) Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol Cell 41(1):93-106 SGD PMID 21211726
  5. submitted by Richard G. Gardner on 2005-11-09

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