Difference between revisions of "YDR143C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002550 YDR143C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SAN1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SAN1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr IV:743871..742039 | |nowrap| Chr IV:743871..742039 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002550 | ||
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| − | '''Description of | + | '''Description of YDR143C:''' Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins; san1 mutations suppress sir4, spt16, and cdc68 mutations, suggesting a role in chromatin silencing<ref name='S000081200'>Gardner RG, et al. (2005) Degradation-mediated protein quality control in the nucleus. Cell 120(6):803-15 {{SGDpaper|S000081200}} PMID 15797381</ref><ref name='S000058946'>Dasgupta A, et al. (2004) Sir Antagonist 1 (San1) is a ubiquitin ligase. J Biol Chem 279(26):26830-8 {{SGDpaper|S000058946}} PMID 15078868</ref><ref name='S000049062'>Xu Q, et al. (1993) The Saccharomyces cerevisiae Cdc68 transcription activator is antagonized by San1, a protein implicated in transcriptional silencing. Mol Cell Biol 13(12):7553-65 {{SGDpaper|S000049062}} PMID 8246972</ref><ref name='S000045142'>Schnell R, et al. (1989) Genetic and molecular characterization of suppressors of SIR4 mutations in Saccharomyces cerevisiae. Genetics 122(1):29-46 |
{{SGDpaper|S000045142}} PMID 2471670</ref> | {{SGDpaper|S000045142}} PMID 2471670</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 08:46, 27 February 2007
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| Systematic name | YDR143C |
| Gene name | SAN1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:743871..742039 |
| Primary SGDID | S000002550 |
Description of YDR143C: Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins; san1 mutations suppress sir4, spt16, and cdc68 mutations, suggesting a role in chromatin silencing[1][2][3][4]
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Protein Details
Protein Function/Process
Nuclear-localized ubiquitin-protein ligase involved in the proteasome-dependent quality control degradation of aberrant nuclear proteins, including sir4-9, cdc68-1, sir3-8, and cdc13-1. [1] [5]
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References
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- ↑ 1.0 1.1 Gardner RG, et al. (2005) Degradation-mediated protein quality control in the nucleus. Cell 120(6):803-15 SGD PMID 15797381
- ↑ Dasgupta A, et al. (2004) Sir Antagonist 1 (San1) is a ubiquitin ligase. J Biol Chem 279(26):26830-8 SGD PMID 15078868
- ↑ Xu Q, et al. (1993) The Saccharomyces cerevisiae Cdc68 transcription activator is antagonized by San1, a protein implicated in transcriptional silencing. Mol Cell Biol 13(12):7553-65 SGD PMID 8246972
- ↑ Schnell R, et al. (1989) Genetic and molecular characterization of suppressors of SIR4 mutations in Saccharomyces cerevisiae. Genetics 122(1):29-46 SGD PMID 2471670
- ↑ submitted by Richard G. Gardner on 2005-11-09
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