YDR072C
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| Systematic name | YDR072C | |
| Gene name | IPT1 | |
| Aliases | KTI6, SYR4 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr IV:591342..589759 | |
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Description of YDR072C: Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media[1][2][3]
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References
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- ↑ Thevissen K, et al. (2000) A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Proc Natl Acad Sci U S A 97(17):9531-6 SGD PMID 10931938
- ↑ Stock SD, et al. (2000) Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups. Antimicrob Agents Chemother 44(5):1174-80 SGD PMID 10770748
- ↑ Dickson RC, et al. (1997) Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J Biol Chem 272(47):29620-5 SGD PMID 9368028
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