YDR072C
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| Systematic name | YDR072C |
| Gene name | IPT1 |
| Aliases | KTI6, SYR4 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:591344..589761 |
| Primary SGDID | S000002479 |
Description of YDR072C: Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin[1][2][3][4]
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Community Commentary
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DNA and RNA Details
Other DNA and RNA Details
Other Topic: expression
Specifically lower expression in phosphorus limited chemostat cultures versus phosphorus excess. [5] [6]
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References
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- ↑ Dickson RC, et al. (1997) Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J Biol Chem 272(47):29620-5 SGD PMID 9368028
- ↑ Stock SD, et al. (2000) Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups. Antimicrob Agents Chemother 44(5):1174-80 SGD PMID 10770748
- ↑ Thevissen K, et al. (2000) A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Proc Natl Acad Sci U S A 97(17):9531-6 SGD PMID 10931938
- ↑ Zink S, et al. (2005) Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin. Eukaryot Cell 4(5):879-89 SGD PMID 15879522
- ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
- ↑ submitted by Viktor Boer on 2003-07-25
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