Difference between revisions of "YDR002W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002409 YDR002W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''YRB1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''YRB1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:453045..453650 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002409 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002409 | ||
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| − | '''Description of YDR002W:''' Ran | + | '''Description of YDR002W:''' Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1<ref name='S000059718'>Baumer M, et al. (2000) Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p. J Biol Chem 275(49):38929-37 {{SGDpaper|S000059718}} PMID 10991951</ref><ref name='S000041438'>Dingwall C, et al. (1995) A family of Ran binding proteins that includes nucleoporins. Proc Natl Acad Sci U S A 92(16):7525-9 {{SGDpaper|S000041438}} PMID 7638224</ref><ref name='S000046566'>Kunzler M, et al. (2000) Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Mol Cell Biol 20(12):4295-308 {{SGDpaper|S000046566}} PMID 10825193</ref><ref name='S000074666'>Kunzler M, et al. (2001) Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects. Genetics 157(3):1089-105 {{SGDpaper|S000074666}} PMID 11238397</ref><ref name='S000050246'>Ouspenski II, et al. (1995) Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. J Biol Chem 270(5):1975-8 {{SGDpaper|S000050246}} PMID 7836422</ref><ref name='S000051618'>Schlenstedt G, et al. (1995) Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J 14(21):5367-78 |
| − | {{SGDpaper| | + | {{SGDpaper|S000051618}} PMID 7489726</ref> |
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 07:45, 23 January 2012
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| Systematic name | YDR002W |
| Gene name | YRB1 |
| Aliases | CST20, HTN1, SFO1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:453045..453650 |
| Primary SGDID | S000002409 |
Description of YDR002W: Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1[1][2][3][4][5][6]
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References
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- ↑ Baumer M, et al. (2000) Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p. J Biol Chem 275(49):38929-37 SGD PMID 10991951
- ↑ Dingwall C, et al. (1995) A family of Ran binding proteins that includes nucleoporins. Proc Natl Acad Sci U S A 92(16):7525-9 SGD PMID 7638224
- ↑ Kunzler M, et al. (2000) Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Mol Cell Biol 20(12):4295-308 SGD PMID 10825193
- ↑ Kunzler M, et al. (2001) Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects. Genetics 157(3):1089-105 SGD PMID 11238397
- ↑ Ouspenski II, et al. (1995) Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. J Biol Chem 270(5):1975-8 SGD PMID 7836422
- ↑ Schlenstedt G, et al. (1995) Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J 14(21):5367-78 SGD PMID 7489726
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