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Systematic name YDR002W
Gene name YRB1
Aliases CST20, HTN1, SFO1
Feature type ORF, Verified
Coordinates Chr IV:453045..453650
Primary SGDID S000002409

Description of YDR002W: Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1[1][2][3][4][5][6]


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  1. Baumer M, et al. (2000) Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p. J Biol Chem 275(49):38929-37 SGD PMID 10991951
  2. Dingwall C, et al. (1995) A family of Ran binding proteins that includes nucleoporins. Proc Natl Acad Sci U S A 92(16):7525-9 SGD PMID 7638224
  3. Kunzler M, et al. (2000) Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Mol Cell Biol 20(12):4295-308 SGD PMID 10825193
  4. Kunzler M, et al. (2001) Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects. Genetics 157(3):1089-105 SGD PMID 11238397
  5. Ouspenski II, et al. (1995) Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. J Biol Chem 270(5):1975-8 SGD PMID 7836422
  6. Schlenstedt G, et al. (1995) Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J 14(21):5367-78 SGD PMID 7489726

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