Difference between revisions of "YCR088W"
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| − | '''Description of YCR088W:''' Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization<ref name='S000043720'>Drubin DG, et al. (1990) Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I. Nature 343(6255):288-90 {{SGDpaper|S000043720}} PMID 2405279</ref><ref name='S000042854'>Mulholland J, et al. (1994) Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol 125(2):381-91 {{SGDpaper|S000042854}} PMID 8163554</ref><ref name='S000074351'>Olazabal IM and Machesky LM (2001) Abp1p and cortactin, new hand-holds for actin. J Cell Biol 154(4):679-82 | + | '''Description of YCR088W:''' Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences<ref name='S000043720'>Drubin DG, et al. (1990) Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I. Nature 343(6255):288-90 {{SGDpaper|S000043720}} PMID 2405279</ref><ref name='S000149711'>Garcia B, et al. (2012) The Importance of Conserved Features of Yeast Actin Binding Protein 1 (Abp1p): the Conditional Nature of Essentiality. Genetics () {{SGDpaper|S000149711}} PMID 22661326</ref><ref name='S000042854'>Mulholland J, et al. (1994) Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol 125(2):381-91 {{SGDpaper|S000042854}} PMID 8163554</ref><ref name='S000074351'>Olazabal IM and Machesky LM (2001) Abp1p and cortactin, new hand-holds for actin. J Cell Biol 154(4):679-82 |
{{SGDpaper|S000074351}} PMID 11514584</ref> | {{SGDpaper|S000074351}} PMID 11514584</ref> | ||
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Latest revision as of 14:05, 22 June 2012
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| Systematic name | YCR088W |
| Gene name | ABP1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr III:265068..266846 |
| Primary SGDID | S000000684 |
Description of YCR088W: Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences[1][2][3][4]
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References
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- ↑ Drubin DG, et al. (1990) Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I. Nature 343(6255):288-90 SGD PMID 2405279
- ↑ Garcia B, et al. (2012) The Importance of Conserved Features of Yeast Actin Binding Protein 1 (Abp1p): the Conditional Nature of Essentiality. Genetics () SGD PMID 22661326
- ↑ Mulholland J, et al. (1994) Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol 125(2):381-91 SGD PMID 8163554
- ↑ Olazabal IM and Machesky LM (2001) Abp1p and cortactin, new hand-holds for actin. J Cell Biol 154(4):679-82 SGD PMID 11514584
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