YCR088W

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Systematic name YCR088W
Gene name ABP1
Aliases
Feature type ORF, Verified
Coordinates Chr III:265068..266846
Primary SGDID S000000684


Description of YCR088W: Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences[1][2][3][4]




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References

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  1. Drubin DG, et al. (1990) Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I. Nature 343(6255):288-90 SGD PMID 2405279
  2. Garcia B, et al. (2012) The Importance of Conserved Features of Yeast Actin Binding Protein 1 (Abp1p): the Conditional Nature of Essentiality. Genetics () SGD PMID 22661326
  3. Mulholland J, et al. (1994) Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol 125(2):381-91 SGD PMID 8163554
  4. Olazabal IM and Machesky LM (2001) Abp1p and cortactin, new hand-holds for actin. J Cell Biol 154(4):679-82 SGD PMID 11514584

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