Difference between revisions of "YCR059C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000655 YCR059C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''YIH1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''YIH1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr III: | + | |nowrap| Chr III:224230..223454 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000655 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000655 | ||
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| − | '''Description of YCR059C:''' | + | '''Description of YCR059C:''' Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT<ref name='S000054053'>Kubota H, et al. (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6 {{SGDpaper|S000054053}} PMID 10801780</ref><ref name='S000082081'>Pereira CM, et al. (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280(31):28316-23 {{SGDpaper|S000082081}} PMID 15937339</ref><ref name='S000076888'>Sattlegger E, et al. (2004) YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem 279(29):29952-62 {{SGDpaper|S000076888}} PMID 15126500</ref><ref name='S000143536'>Sattlegger E, et al. (2011) Gcn1 and Actin Binding to Yih1: IMPLICATIONS FOR ACTIVATION OF THE eIF2 KINASE GCN2. J Biol Chem 286(12):10341-55 {{SGDpaper|S000143536}} PMID 21239490</ref><ref name='S000148776'>Waller T, et al. (2012) Evidence that Yih1 resides in a complex with ribosomes.LID - 10.1111/j.1742-4658.2012.08553.x [doi] FEBS J () |
| − | {{SGDpaper| | + | {{SGDpaper|S000148776}} PMID 22404850</ref> |
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Latest revision as of 14:05, 1 May 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YCR059C |
| Gene name | YIH1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr III:224230..223454 |
| Primary SGDID | S000000655 |
Description of YCR059C: Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT[1][2][3][4][5]
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References
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- ↑ Kubota H, et al. (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6 SGD PMID 10801780
- ↑ Pereira CM, et al. (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280(31):28316-23 SGD PMID 15937339
- ↑ Sattlegger E, et al. (2004) YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem 279(29):29952-62 SGD PMID 15126500
- ↑ Sattlegger E, et al. (2011) Gcn1 and Actin Binding to Yih1: IMPLICATIONS FOR ACTIVATION OF THE eIF2 KINASE GCN2. J Biol Chem 286(12):10341-55 SGD PMID 21239490
- ↑ Waller T, et al. (2012) Evidence that Yih1 resides in a complex with ribosomes.LID - 10.1111/j.1742-4658.2012.08553.x [doi] FEBS J () SGD PMID 22404850
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