YCR059C
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| Systematic name | YCR059C |
| Gene name | YIH1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr III:224230..223454 |
| Primary SGDID | S000000655 |
Description of YCR059C: Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT[1][2][3][4][5]
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References
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- ↑ Kubota H, et al. (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6 SGD PMID 10801780
- ↑ Pereira CM, et al. (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280(31):28316-23 SGD PMID 15937339
- ↑ Sattlegger E, et al. (2004) YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem 279(29):29952-62 SGD PMID 15126500
- ↑ Sattlegger E, et al. (2011) Gcn1 and Actin Binding to Yih1: IMPLICATIONS FOR ACTIVATION OF THE eIF2 KINASE GCN2. J Biol Chem 286(12):10341-55 SGD PMID 21239490
- ↑ Waller T, et al. (2012) Evidence that Yih1 resides in a complex with ribosomes.LID - 10.1111/j.1742-4658.2012.08553.x [doi] FEBS J () SGD PMID 22404850
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