YCL061C
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| Systematic name | YCL061C | |
| Gene name | MRC1 | |
| Aliases | YCL060C | |
| Feature type | ORF, Verified | |
| Coordinates | Chr III:22106..18816 | |
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Description of YCL061C: S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p; protein involved in replication checkpoint[1][2]
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References
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- ↑ Katou Y, et al. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424(6952):1078-83 SGD PMID 12944972
- ↑ Osborn AJ and Elledge SJ (2003) Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 17(14):1755-67 SGD PMID 12865299
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