YCL061C
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| Systematic name | YCL061C |
| Gene name | MRC1 |
| Aliases | YCL060C |
| Feature type | ORF, Verified |
| Coordinates | Chr III:22106..18816 |
| Primary SGDID | S000000566 |
Description of YCL061C: S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres[1][2][3][4]
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Community Commentary
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DNA and RNA Details
Other DNA and RNA Details
Other Topic: expression
Specifically higher expression in nitrogen limited chemostat cultures versus nitrogen excess. [5] [6]
The MRC1 deletion in the systematic deletion collection uses a start codon 3' of the real start codon. Thus, it truncates and DAmPs the gene rather than deleting it.
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References
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- ↑ Katou Y, et al. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424(6952):1078-83 SGD PMID 12944972
- ↑ Lou H, et al. (2008) Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint. Mol Cell 32(1):106-17 SGD PMID 18851837
- ↑ Osborn AJ and Elledge SJ (2003) Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 17(14):1755-67 SGD PMID 12865299
- ↑ Tsolou A and Lydall D (2007) Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1. DNA Repair (Amst) 6(11):1607-1617 SGD PMID 17618841
- ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
- ↑ submitted by Viktor Boer on 2003-07-25
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References
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