Difference between revisions of "YCL061C"
SGDwikiBot (talk | contribs) (Automated import of articles) |
SGDwikiBot (talk | contribs) (Automated import of articles) |
||
| (5 intermediate revisions by 2 users not shown) | |||
| Line 4: | Line 4: | ||
{|{{Prettytable}} align = 'right' width = '200px' | {|{{Prettytable}} align = 'right' width = '200px' | ||
|- | |- | ||
| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000566 YCL061C] |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MRC1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MRC1 '' | ||
| Line 18: | Line 18: | ||
|} | |} | ||
<br> | <br> | ||
| − | '''Description of YCL061C:''' S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres<ref name=' | + | '''Description of YCL061C:''' S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres<ref name='S000073860'>Katou Y, et al. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424(6952):1078-83 {{SGDpaper|S000073860}} PMID 12944972</ref><ref name='S000128058'>Lou H, et al. (2008) Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint. Mol Cell 32(1):106-17 {{SGDpaper|S000128058}} PMID 18851837</ref><ref name='S000073790'>Osborn AJ and Elledge SJ (2003) Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 17(14):1755-67 {{SGDpaper|S000073790}} PMID 12865299</ref><ref name='S000123337'>Tsolou A and Lydall D (2007) Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1. DNA Repair (Amst) 6(11):1607-1617 |
| − | {{SGDpaper| | + | {{SGDpaper|S000123337}} PMID 17618841</ref> |
<br> | <br> | ||
<br> | <br> | ||
| Line 38: | Line 38: | ||
{{ShortCenteredHR}} | {{ShortCenteredHR}} | ||
| + | |||
| + | The MRC1 deletion in the systematic deletion collection uses a start codon 3' of the real start codon. Thus, it truncates and DAmPs the gene rather than deleting it. | ||
| Line 50: | Line 52: | ||
| + | <protect> | ||
| + | |||
| + | ==References== | ||
| + | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
| + | {{RefHelp}} | ||
| + | </protect> | ||
<protect> | <protect> | ||
==References== | ==References== | ||
Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YCL061C |
| Gene name | MRC1 |
| Aliases | YCL060C |
| Feature type | ORF, Verified |
| Coordinates | Chr III:22106..18816 |
| Primary SGDID | S000000566 |
Description of YCL061C: S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres[1][2][3][4]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
DNA and RNA Details
Other DNA and RNA Details
Other Topic: expression
Specifically higher expression in nitrogen limited chemostat cultures versus nitrogen excess. [5] [6]
The MRC1 deletion in the systematic deletion collection uses a start codon 3' of the real start codon. Thus, it truncates and DAmPs the gene rather than deleting it.
<protect>
References
See Help:References on how to add references
- ↑ Katou Y, et al. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424(6952):1078-83 SGD PMID 12944972
- ↑ Lou H, et al. (2008) Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint. Mol Cell 32(1):106-17 SGD PMID 18851837
- ↑ Osborn AJ and Elledge SJ (2003) Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 17(14):1755-67 SGD PMID 12865299
- ↑ Tsolou A and Lydall D (2007) Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1. DNA Repair (Amst) 6(11):1607-1617 SGD PMID 17618841
- ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
- ↑ submitted by Viktor Boer on 2003-07-25
See Help:Categories on how to add the wiki page for this gene to a Category </protect> <protect>
References
See Help:References on how to add references
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
