Difference between revisions of "YBR246W"
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| − | '''Description of YBR246W:''' | + | '''Description of YBR246W:''' Protein required for last step of diphthamide biosynthesis; deletion leads to accumulation of diphthine, which is the enzymatic product of the second step of the biosynthesis; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription<ref name='S000070264'>Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 {{SGDpaper|S000070264}} PMID 12134085</ref><ref name='S000129563'>Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19 {{SGDpaper|S000129563}} PMID 19270272</ref><ref name='S000146585'>Shi Y, et al. (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell () {{SGDpaper|S000146585}} PMID 21880895</ref><ref name='S000147862'>Su X, et al. (2011) YBR246W Is Required for the Third Step of Diphthamide Biosynthesis. J Am Chem Soc () |
{{SGDpaper|S000147862}} PMID 22188241</ref> | {{SGDpaper|S000147862}} PMID 22188241</ref> | ||
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Latest revision as of 14:05, 5 June 2012
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| Systematic name | YBR246W |
| Gene name | RRT2 |
| Aliases | ERE1 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:711591..712754 |
| Primary SGDID | S000000450 |
Description of YBR246W: Protein required for last step of diphthamide biosynthesis; deletion leads to accumulation of diphthine, which is the enzymatic product of the second step of the biosynthesis; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription[1][2][3][4]
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References
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- ↑ Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 SGD PMID 12134085
- ↑ Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19 SGD PMID 19270272
- ↑ Shi Y, et al. (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell () SGD PMID 21880895
- ↑ Su X, et al. (2011) YBR246W Is Required for the Third Step of Diphthamide Biosynthesis. J Am Chem Soc () SGD PMID 22188241
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