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Systematic name YBR246W
Gene name RRT2
Aliases ERE1
Feature type ORF, Verified
Coordinates Chr II:711591..712754
Primary SGDID S000000450

Description of YBR246W: Protein required for last step of diphthamide biosynthesis; deletion leads to accumulation of diphthine, which is the enzymatic product of the second step of the biosynthesis; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription[1][2][3][4]


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  1. Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 SGD PMID 12134085
  2. Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19 SGD PMID 19270272
  3. Shi Y, et al. (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell () SGD PMID 21880895
  4. Su X, et al. (2011) YBR246W Is Required for the Third Step of Diphthamide Biosynthesis. J Am Chem Soc () SGD PMID 22188241

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