YBR102C
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| Systematic name | YBR102C | |
| Gene name | EXO84 | |
| Aliases | USA3 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr II:447317..445056 | |
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Description of YBR102C: Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis[1][2][3]
Contents
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Interactions
Two Hybrid
Two Hybrid interaction with Prp8
Prp8 binds to C-terminus of Exo84 [4] [5]
Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [1] [6]
References
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- ↑ 1.0 1.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Awasthi S, et al. (2001) New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing. J Biol Chem 276(33):31004-15 SGD PMID 11425851
- ↑ Guo W, et al. (1999) Exo84p is an exocyst protein essential for secretion. J Biol Chem 274(33):23558-64 SGD PMID 10438536
- ↑ Kuhn AN and Brow DA (2000) Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155(4):1667-82 SGD PMID 10924465
- ↑ submitted by Richard Grainger on 2003-04-11
- ↑ submitted by Jeff Ubersax on 2004-01-21
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