Difference between revisions of "YBR102C"

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=== Interactions ===
 
[[Category:Topic:Interactions]]
 
==== Two Hybrid ====
 
[[Category:Topic:Interactions:Two Hybrid]]
 
Two Hybrid interaction with Prp8 [[Category:Two Hybrid Interactions with Prp8]]<br>
 
Prp8 binds to C-terminus of Exo84 <ref name='S000052181'>Kuhn AN and Brow DA (2000) Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155(4):1667-82 {{SGDpaper|S000052181}} PMID 10924465</ref> <ref name = 'CAset9267-2003-04-11'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9267 Richard Grainger] on 2003-04-11</ref>
 
 
{{ShortCenteredHR}}
 
=== Protein Details ===
 
[[Category:Topic:Protein Details]]
 
==== Protein Modification ====
 
[[Category:Topic:Protein Details:Protein Modification]]
 
'''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]]
 
 
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-21'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-21</ref>
 
 
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==Community Commentary==
 
==Community Commentary==

Revision as of 11:51, 24 January 2007

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Systematic name YBR102C
Gene name EXO84
Aliases USA3
Feature type ORF, Verified
Coordinates Chr II:447317..445056
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Description of YBR102C: Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis[1][2][3]



Community Commentary

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Interactions

Two Hybrid

Two Hybrid interaction with Prp8
Prp8 binds to C-terminus of Exo84 [4] [5]


Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [1] [6]


References

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  1. 1.0 1.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  2. Awasthi S, et al. (2001) New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing. J Biol Chem 276(33):31004-15 SGD PMID 11425851
  3. Guo W, et al. (1999) Exo84p is an exocyst protein essential for secretion. J Biol Chem 274(33):23558-64 SGD PMID 10438536
  4. Kuhn AN and Brow DA (2000) Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155(4):1667-82 SGD PMID 10924465
  5. submitted by Richard Grainger on 2003-04-11
  6. submitted by Jeff Ubersax on 2004-01-21

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