Difference between revisions of "YBL078C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YBL078C YBL078C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000174 YBL078C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''ATG8 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''ATG8 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr II:80728..80375
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|nowrap| Chr II:80731..80378
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000174
 
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'''Description of {{PAGENAME}}:''' Protein required for autophagy; modified by the serial action of Atg4p, Atg7p, and Atg3p, and conjugated at the C terminus with phosphatidylethanolamine, to become the form essential for generation of autophagosomes<ref name='S000059720'>Ichimura Y, et al. (2000) A ubiquitin-like system mediates protein lipidation. Nature 408(6811):488-92 {{SGDpaper|S000059720}} PMID 11100732</ref><ref name='S000051835'>Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74
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'''Description of YBL078C:''' Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation<ref name='S000059720'>Ichimura Y, et al. (2000) A ubiquitin-like system mediates protein lipidation. Nature 408(6811):488-92 {{SGDpaper|S000059720}} PMID 11100732</ref><ref name='S000059897'>Kirisako T, et al. (2000) The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol 151(2):263-76 {{SGDpaper|S000059897}} PMID 11038174</ref><ref name='S000146892'>Nair U, et al. (2011) SNARE proteins are required for macroautophagy. Cell 146(2):290-302 {{SGDpaper|S000146892}} PMID 21784249</ref><ref name='S000123418'>Nakatogawa H, et al. (2007) Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion. Cell 130(1):165-78 {{SGDpaper|S000123418}} PMID 17632063</ref><ref name='S000051835'>Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 {{SGDpaper|S000051835}} PMID 8224160</ref><ref name='S000127124'>Xie Z, et al. (2008) Atg8 Controls Phagophore Expansion during Autophagosome Formation. Mol Biol Cell 19(8):3290-8
  {{SGDpaper|S000051835}} PMID 8224160</ref>
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  {{SGDpaper|S000127124}} PMID 18508918</ref>
 
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==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YBL078C
Gene name ATG8
Aliases APG8, AUT7, CVT5
Feature type ORF, Verified
Coordinates Chr II:80731..80378
Primary SGDID S000000174


Description of YBL078C: Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation[1][2][3][4][5][6]




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References

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  1. Ichimura Y, et al. (2000) A ubiquitin-like system mediates protein lipidation. Nature 408(6811):488-92 SGD PMID 11100732
  2. Kirisako T, et al. (2000) The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol 151(2):263-76 SGD PMID 11038174
  3. Nair U, et al. (2011) SNARE proteins are required for macroautophagy. Cell 146(2):290-302 SGD PMID 21784249
  4. Nakatogawa H, et al. (2007) Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion. Cell 130(1):165-78 SGD PMID 17632063
  5. Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 SGD PMID 8224160
  6. Xie Z, et al. (2008) Atg8 Controls Phagophore Expansion during Autophagosome Formation. Mol Biol Cell 19(8):3290-8 SGD PMID 18508918

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