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Systematic name YBL078C
Gene name ATG8
Aliases APG8, AUT7, CVT5
Feature type ORF, Verified
Coordinates Chr II:80731..80378
Primary SGDID S000000174

Description of YBL078C: Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation[1][2][3][4][5][6]


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  1. Ichimura Y, et al. (2000) A ubiquitin-like system mediates protein lipidation. Nature 408(6811):488-92 SGD PMID 11100732
  2. Kirisako T, et al. (2000) The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol 151(2):263-76 SGD PMID 11038174
  3. Nair U, et al. (2011) SNARE proteins are required for macroautophagy. Cell 146(2):290-302 SGD PMID 21784249
  4. Nakatogawa H, et al. (2007) Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion. Cell 130(1):165-78 SGD PMID 17632063
  5. Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 SGD PMID 8224160
  6. Xie Z, et al. (2008) Atg8 Controls Phagophore Expansion during Autophagosome Formation. Mol Biol Cell 19(8):3290-8 SGD PMID 18508918

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