Difference between revisions of "YBL024W"
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| − | '''Description of YBL024W:''' S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120<ref name='S000052672'>Motorin Y and Grosjean H (1999) Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. RNA 5(8):1105-18 {{SGDpaper|S000052672}} PMID 10445884</ref><ref name='S000053868'>Wu P, et al. (1998) NCL1, a novel gene for a non-essential nuclear protein in Saccharomyces cerevisiae. Gene 220(1-2):109-17 | + | '''Description of YBL024W:''' S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120<ref name='S000150043'>Chan CT, et al. (2012) Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nat Commun 3():937 {{SGDpaper|S000150043}} PMID 22760636</ref><ref name='S000052672'>Motorin Y and Grosjean H (1999) Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. RNA 5(8):1105-18 {{SGDpaper|S000052672}} PMID 10445884</ref><ref name='S000053868'>Wu P, et al. (1998) NCL1, a novel gene for a non-essential nuclear protein in Saccharomyces cerevisiae. Gene 220(1-2):109-17 |
{{SGDpaper|S000053868}} PMID 9767141</ref> | {{SGDpaper|S000053868}} PMID 9767141</ref> | ||
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Latest revision as of 14:05, 7 August 2012
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| Systematic name | YBL024W |
| Gene name | NCL1 |
| Aliases | TRM4 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:172534..174588 |
| Primary SGDID | S000000120 |
Description of YBL024W: S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120[1][2][3]
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References
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- ↑ Chan CT, et al. (2012) Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nat Commun 3():937 SGD PMID 22760636
- ↑ Motorin Y and Grosjean H (1999) Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. RNA 5(8):1105-18 SGD PMID 10445884
- ↑ Wu P, et al. (1998) NCL1, a novel gene for a non-essential nuclear protein in Saccharomyces cerevisiae. Gene 220(1-2):109-17 SGD PMID 9767141
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