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Systematic name YBL024W
Gene name NCL1
Aliases TRM4
Feature type ORF, Verified
Coordinates Chr II:172534..174588
Primary SGDID S000000120

Description of YBL024W: S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120[1][2][3]


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  1. Chan CT, et al. (2012) Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nat Commun 3():937 SGD PMID 22760636
  2. Motorin Y and Grosjean H (1999) Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. RNA 5(8):1105-18 SGD PMID 10445884
  3. Wu P, et al. (1998) NCL1, a novel gene for a non-essential nuclear protein in Saccharomyces cerevisiae. Gene 220(1-2):109-17 SGD PMID 9767141

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