Difference between revisions of "YAL019W"

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'''Description of YAL019W:''' Conserved member of the Snf2p family with ATP-dependent chromatin remodeling activity; has a role in silencing; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies<ref name='S000132810'>Awad S, et al. (2010) The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem 285(13):9477-84 {{SGDpaper|S000132810}} PMID 20075079</ref><ref name='S000040251'>Clark MW, et al. (1992) Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I. Yeast 8(2):133-45 {{SGDpaper|S000040251}} PMID 1561836</ref><ref name='S000132432'>Neves-Costa A, et al. (2009) The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. PLoS One 4(12):e8111 {{SGDpaper|S000132432}} PMID 19956593</ref><ref name='S000052609'>Ouspenski II, et al. (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8 {{SGDpaper|S000052609}} PMID 10454593</ref><ref name='S000117178'>Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 {{SGDpaper|S000117178}} PMID 16823961</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
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'''Description of YAL019W:''' Conserved member of the Snf2p family with ATP-dependent chromatin remodeling activity; involved in double strand break (DSB) response; has a role in silencing; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies<ref name='S000132810'>Awad S, et al. (2010) The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem 285(13):9477-84 {{SGDpaper|S000132810}} PMID 20075079</ref><ref name='S000040251'>Clark MW, et al. (1992) Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I. Yeast 8(2):133-45 {{SGDpaper|S000040251}} PMID 1561836</ref><ref name='S000151022'>Costelloe T, et al. (2012) The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.LID - 10.1038/nature11353 [doi] Nature () {{SGDpaper|S000151022}} PMID 22960744</ref><ref name='S000132432'>Neves-Costa A, et al. (2009) The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. PLoS One 4(12):e8111 {{SGDpaper|S000132432}} PMID 19956593</ref><ref name='S000052609'>Ouspenski II, et al. (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8 {{SGDpaper|S000052609}} PMID 10454593</ref><ref name='S000117178'>Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 {{SGDpaper|S000117178}} PMID 16823961</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
 
  {{SGDpaper|S000074306}} PMID 14574415</ref>
 
  {{SGDpaper|S000074306}} PMID 14574415</ref>
 
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Revision as of 14:05, 25 September 2012

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Systematic name YAL019W
Gene name FUN30
Aliases
Feature type ORF, Verified
Coordinates Chr I:114919..118314
Primary SGDID S000000017


Description of YAL019W: Conserved member of the Snf2p family with ATP-dependent chromatin remodeling activity; involved in double strand break (DSB) response; has a role in silencing; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies[1][2][3][4][5][6][7]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [7] [8]





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References

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  1. Awad S, et al. (2010) The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem 285(13):9477-84 SGD PMID 20075079
  2. Clark MW, et al. (1992) Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I. Yeast 8(2):133-45 SGD PMID 1561836
  3. Costelloe T, et al. (2012) The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.LID - 10.1038/nature11353 [doi] Nature () SGD PMID 22960744
  4. Neves-Costa A, et al. (2009) The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. PLoS One 4(12):e8111 SGD PMID 19956593
  5. Ouspenski II, et al. (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8 SGD PMID 10454593
  6. Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD PMID 16823961
  7. 7.0 7.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  8. submitted by Jeff Ubersax on 2004-01-21

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