From SGD-Wiki
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YAL019W
Gene name FUN30
Feature type ORF, Verified
Coordinates Chr I:114919..118314
Primary SGDID S000000017

Description of YAL019W: Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; involved in double-strand break (DSB) response; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies[1][2][3][4][5][6][7][8]


Community Commentary

About Community Commentary. Please share your knowledge!

Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [8] [9]



See Help:References on how to add references

  1. Awad S, et al. (2010) The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem 285(13):9477-84 SGD PMID 20075079
  2. Clark MW, et al. (1992) Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I. Yeast 8(2):133-45 SGD PMID 1561836
  3. Costelloe T, et al. (2012) The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.LID - 10.1038/nature11353 [doi] Nature () SGD PMID 22960744
  4. Durand-Dubief M, et al. (2012) SWI/SNF-Like Chromatin Remodeling Factor Fun30 Supports Point Centromere Function in S. cerevisiae. PLoS Genet 8(9):e1002974 SGD PMID 23028372
  5. Neves-Costa A, et al. (2009) The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. PLoS One 4(12):e8111 SGD PMID 19956593
  6. Ouspenski II, et al. (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8 SGD PMID 10454593
  7. Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD PMID 16823961
  8. 8.0 8.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  9. submitted by Jeff Ubersax on 2004-01-21

See Help:Categories on how to add the wiki page for this gene to a Category </protect>