YOR294W
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| Systematic name | YOR294W |
| Gene name | RRS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:868340..868951 |
| Primary SGDID | S000005820 |
Description of YOR294W: Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice[1][2][3][4][5]
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References
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- ↑ Fossale E, et al. (2002) Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice. Hum Mol Genet 11(19):2233-41 SGD PMID 12217951
- ↑ Horigome C, et al. (2011) Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.LID - 10.1038/emboj.2011.267 [doi] EMBO J () SGD PMID 21822217
- ↑ Miyoshi K, et al. (2004) Rrs1p, a ribosomal protein L11-binding protein, is required for nuclear export of the 60S pre-ribosomal subunit in Saccharomyces cerevisiae. FEBS Lett 565(1-3):106-10 SGD PMID 15135061
- ↑ Morita D, et al. (2002) Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. J Biol Chem 277(32):28780-6 SGD PMID 12048200
- ↑ Tsuno A, et al. (2000) RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. Mol Cell Biol 20(6):2066-74 SGD PMID 10688653
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