YOR294W

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Systematic name YOR294W
Gene name RRS1
Aliases
Feature type ORF, Verified
Coordinates Chr XV:868340..868951
Primary SGDID S000005820


Description of YOR294W: Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice[1][2][3][4][5]




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References

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  1. Jump up Fossale E, et al. (2002) Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice. Hum Mol Genet 11(19):2233-41 SGD PMID 12217951
  2. Jump up Horigome C, et al. (2011) Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.LID - 10.1038/emboj.2011.267 [doi] EMBO J () SGD PMID 21822217
  3. Jump up Miyoshi K, et al. (2004) Rrs1p, a ribosomal protein L11-binding protein, is required for nuclear export of the 60S pre-ribosomal subunit in Saccharomyces cerevisiae. FEBS Lett 565(1-3):106-10 SGD PMID 15135061
  4. Jump up Morita D, et al. (2002) Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. J Biol Chem 277(32):28780-6 SGD PMID 12048200
  5. Jump up Tsuno A, et al. (2000) RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. Mol Cell Biol 20(6):2066-74 SGD PMID 10688653

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